Crystallisation screening and development

Often when an API enters into development the solid form is not crystalline. Solid Form Solutions offers an extensive crystallisation service focusing on obtaining a crystalline and easily isolated form of the drug.

Our program employs a very large number of crystallisation experiments and aims to deliver a process transferable to a scale-up. We also use surface modification technology to encourage crystallisation in the most stubborn compounds.

Combined with our knowledge of downstream processing SFS will deliver a scalable solution.

To assess the physical properties of crystalline material we employ the most advanced techniques in solid-state characterisation which include:

  • X-Ray Powder Diffraction (XRPD)
  • Differential Scanning Calorimetry (DSC)
  • Thermal Gravimetric Analysis (TGA)

Whilst also interrogating our materials using a range of developability tests, such as:

  • Dynamic Vapor Sorption (DVS)
  • Thermodynamic Solubility
  • Storage Tests

Crystallisation Dynamics:
This plot shows three important elements of API crystallisation.

Crystallisation Dynamics

Solid Form Solutions has a wide expertise in understanding and controlling these dynamics to establish or improve the crystallisation of your API for development or scale up purposes.